Antitubercular Drug and Antimalarial Drug Induced Hepatotoxicity and Its Protection by Selaginella Corymbosa Leaves Extract
نویسندگان
چکیده
In the present study, the hepatoprotective activity of hydroalcoholic extract of Selaginella corymbosa leaves was investigated. Qualitative test confirmed the presence of flavonoids, sterols and saponins in the extract. The extract was studied for isoniazid and chloroquine induced hepatic injury using 500mg/kg oral dose in albino rats. The changes were assessed by serum enzyme profile, which includes glutamate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPT), direct bilirubin and total bilirubin levels. Histo pathological study was performed to observe the cellular damage of liver. There was a significant reversal of biochemical and histopathological changes induced by isoniazid and chloroquine in rats by hydroalcoholic extract treatment.This study was therefore undertaken to demonstrate the hepatoprotective activity of hydroalcoholic extract of Selaginella corymbosa against isoniazid (INH) and chloroquine induced hepatotoxicity in rats.
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